Defiance 2050 was a re-release of Trion Worlds' 2013 online shooter Defiance, a tie-in to the Syfy TV series. It is set in the San Francisco Bay Area years after a war between humans and the alien Votans, whose terraforming technology reshaped the Earth. You play an Ark Hunter.

It was a third-person MMO shooter: the map, story and missions carried over from the original, while the classes were replaced with four new ones, each with its own power tree. Players drove vehicles, hundreds gathered for world events against aliens, four-person squads ran story instances, and PvP included 64-versus-64 battles.

The game closed on 29 April 2021 together with the original Defiance, when owner Gamigo shut the servers down. In 2025 Fawkes Games licensed both games and relaunched the original 2013 version on PC; 2050 has not returned so far.